Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

Chlornaphazine CAS NO 494-03-1

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CAS No.:494-03-1

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Content:99.90%

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Benzo-Tepa CAS NO 4110-66-1

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CAS No.:4110-66-1

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Ritrosulfan CAS NO 4148-16-7

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CAS No.:4148-16-7

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2-[[4-[Bis(2-Chloroethyl)Amino]-2-Methylphenyl]Azo]Benzoic Acid CAS NO 4213-40-5

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CAS No.:4213-40-5

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N,n-Bis(2-Chloroethyl)-2,3-Dimethoxybenzenamine CAS NO 4213-41-6

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CAS No.:4213-41-6

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Dacarbazine CAS NO 4243-04-3

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CAS No.:4243-04-3

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3-[3-[Bis(2-Chloroethyl)Amino]Phenyl]Propanoic Acid CAS NO 4252-25-9

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CAS No.:4252-25-9

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Dacarbazine CAS NO 4342-03-4

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CAS No.:4342-03-4

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