Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

Diamminedichloroplatinum CAS NO 26035-31-4

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CAS No.:26035-31-4

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Bis-(2-Chloro-Ethyl)-(2-Methoxy-Ethyl)-Amine CAS NO 26112-92-5

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CAS No.:26112-92-5

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N,n-Bis(2-Chloroethyl)-p-Butoxyaniline CAS NO 27077-15-2

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CAS No.:27077-15-2

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1-[6-(Carbamoyl-Nitroso-Amino)Hexyl]-1-Nitroso-Urea CAS NO 27640-22-8

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CAS No.:27640-22-8

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Bis(2-Choroethyl)-2-Methoxyethylamine CAS NO 27807-62-1

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CAS No.:27807-62-1

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5-(3-(2-Chloroethyl)Triazen-1-Yl)Imidazole-4-Carboxamide CAS NO 28177-14-2

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CAS No.:28177-14-2

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Prednimustine CAS NO 29069-24-7

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CAS No.:29069-24-7

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2H-1,3,2-Oxazaphosphorine, 2-(1-Aziridinyl)-3-(2-Chloroethyl)Tetrahydro-, 2-Oxide CAS NO 29102-47-4

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CAS No.:29102-47-4

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