Penicillins
Penicillins
Penicillins are β-lactam antibiotics that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, resulting in cell lysis. They include narrow-spectrum, broad-spectrum, aminopenicillins, antistaphylococcal penicillins, and antipseudomonal penicillins. Penicillins are widely used for respiratory infections, skin infections, syphilis, endocarditis, and streptococcal diseases. Their excellent safety profile and pediatric suitability make them foundational antibiotics. Resistance mediated by β-lactamases, altered PBPs, and efflux mechanisms remains a major challenge, often requiring combination therapy with β-lactamase inhibitors. Penicillins continue to play an essential role in global clinical practice.
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