Antihistamines
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Antihistamines
Antihistamines are APIs that block histamine H1 or H2 receptors to relieve symptoms triggered by allergic reactions, including sneezing, rhinorrhea, urticaria, conjunctival irritation, and pruritus. First-generation antihistamines penetrate the central nervous system and may cause sedation, while second-generation agents offer improved selectivity, minimal drowsiness, and longer duration of action. These APIs are widely used in allergic rhinitis, chronic urticaria, seasonal allergies, insect bite reactions, and dermatologic disorders. Their formulations include tablets, syrups, dissolvable films, injectables, and ophthalmic or nasal preparations. With strong clinical effectiveness and broad safety across age groups, antihistamines remain foundational medications in allergy management.
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