Description

[2-[(8S,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] propanoate, 2-(hydroxymethyl)-4-[1-hydroxy-2-(tert-butylamino)ethyl]phenol is a high-purity, complex synthetic steroid derivative designed for advanced pharmaceutical research and development. This compound is critical for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents targeting inflammatory and hormonal pathways. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of next-generation corticosteroids and specialized receptor modulators.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel corticosteroid analogs and other steroidal active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new anti-inflammatory and immunosuppressive drugs.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Preclinical Studies: Utilized in pharmacological and toxicological research to investigate the efficacy and safety profiles of new steroidal compounds.
• Process Chemistry: Applied in the scale-up and optimization of synthetic routes for complex steroid molecules within pilot plants and manufacturing settings.

Basic Information

Product Name	[2-[(8S,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] propanoate, 2-(hydroxymethyl)-4-[1-hydroxy-2-(tert-butylamino)ethyl]phenol
CAS No.	93686-59-0
Molecular Formula	C36H48ClNO8
Molecular Weight	658.22 g/mol
Synonyms	9-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionate 21-(3-carboxypropionate); Clobetasol propionate impurity; Clobetasol propionate related compound; Steroid derivative CAS 93686-59-0; 17α-[(1-Oxopropoxy)acetyl]oxy]-9-chloro-11β-hydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid γ-lactone (mixed with fenoterol derivative); Complex Corticosteroid Intermediate
EINECS	Contact for details

Quality Control

Our [2-[(8S,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] propanoate, 2-(hydroxymethyl)-4-[1-hydroxy-2-(tert-butylamino)ethyl]phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.