Description

Cholinophyllin CAS NO 146-71-4 is a specialized pharmaceutical intermediate and research chemical, also known as 7-(2-Hydroxyethyl)theophylline. This compound is of significant interest for its role as a precursor in the synthesis of choline theophyllinate, a key bronchodilator agent. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in developing and producing respiratory medications. Its consistent quality and reliable supply are critical for ensuring the efficacy and safety of downstream pharmaceutical products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of choline theophyllinate (oxtriphylline), a widely used bronchodilator for treating asthma, chronic bronchitis, and other respiratory conditions.
• Active Pharmaceutical Ingredient (API) Development: Serves as a building block in research and development for novel theophylline derivatives and other xanthine-based therapeutics.
• Biochemical Research: Used in pharmacological studies to investigate adenosine receptor antagonism, phosphodiesterase inhibition, and related metabolic pathways.
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC, GC, or spectroscopic methods to ensure purity and identity in pharmaceutical production.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, specialized chemical entities.

Basic Information

Product Name	Cholinophyllin
CAS No.	146-71-4
Molecular Formula	C9H12N4O3
Molecular Weight	224.22 g/mol
Synonyms	7-(2-Hydroxyethyl)theophylline; Theophylline-7-ethanol; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxyethyl)-; Choline Theophyllinate Impurity; Oxtriphylline Related Compound; 1,3-Dimethyl-7-(2-hydroxyethyl)xanthine; 7-Hydroxyethyltheophylline
EINECS	205-681-7

Quality Control

Our Cholinophyllin is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical applications. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment. We can support compliance with various pharmacopeial standards (such as USP/EP) for specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.