Description

(8Alpha,9R)-10,11-Dihydro-6'-Methoxycinchonan-9-Ol Monohydrochloride is a high-purity, cinchona alkaloid derivative with significant utility in asymmetric synthesis and pharmaceutical research. This compound serves as a critical chiral building block and catalyst precursor, enabling the production of enantiomerically pure substances essential for advanced drug development. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel therapeutic agents and high-value specialty chemicals.

Application

• Asymmetric Synthesis Catalyst: Employed as a chiral ligand or catalyst precursor in enantioselective reactions, such as asymmetric dihydroxylation and aminohydroxylation.
• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for antimalarial and antiarrhythmic drugs.
• Chiral Resolution Agent: Used in the separation of racemic mixtures to isolate specific enantiomers with desired biological activity.
• Organic Synthesis Research: A valuable reagent in academic and industrial laboratories for methodological development in stereoselective synthesis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	(8Alpha,9R)-10,11-Dihydro-6'-Methoxycinchonan-9-Ol Monohydrochloride
CAS No.	1668-97-9
Molecular Formula	C₂₀H₂₅ClN₂O₂
Molecular Weight	360.88 g/mol
Synonyms	10,11-Dihydro-6'-methoxycinchonan-9-ol, monohydrochloride, (8α,9R)-; Dihydroquinidine Hydrochloride; (8α,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol Hydrochloride; Hydroquinidine Hydrochloride; NSC 269956; Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, monohydrochloride, (8α,9R)-; Dihydroquinidine HCl
EINECS	Contact for details

Quality Control

Our (8Alpha,9R)-10,11-Dihydro-6'-Methoxycinchonan-9-Ol Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets stringent specifications for research and production use. Certificates of Analysis (COA) documenting all test results are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.