Description

(3aS,4S,5S,6E,11S,11aS)-5-(Acetyloxy)-2,3,3a,4,5,8,9,10,11,11a-decahydro-11-hydroxy-3,10-bis(methylene)-4-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxocyclodeca[b]furan-6-carboxylic acid methyl ester is a complex, high-purity sesquiterpene lactone derivative with significant biological activity. This compound is valued as a critical advanced pharmaceutical intermediate and a versatile scaffold for medicinal chemistry research. It is primarily sought by research institutions and pharmaceutical developers working on novel therapeutic agents, particularly in the fields of oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those targeting cancer and inflammatory pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in laboratories.
• Biochemical Research: Utilized in studies investigating cellular signaling pathways and enzyme interactions due to its specific biological activity.
• Process Chemistry Development: Acts as a model compound for developing and scaling up complex synthetic routes in pilot plants.

Basic Information

Item	Details
Product Name	(3aS,4S,5S,6E,11S,11aS)-5-(Acetyloxy)-2,3,3a,4,5,8,9,10,11,11a-decahydro-11-hydroxy-3,10-bis(methylene)-4-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxocyclodeca[b]furan-6-carboxylic acid methyl ester
CAS No.	92356-80-4
Molecular Formula	C₂₄H₃₀O₉
Molecular Weight	462.49 g/mol
Synonyms	Methyl (3aS,4S,5S,6E,11S,11aS)-5-(acetyloxy)-11-hydroxy-4-[(Z)-2-methylbut-2-enoyl]oxy-3,10-bis(methylene)-2-oxo-2,3,3a,4,5,8,9,10,11,11a-decahydrocyclodeca[b]furan-6-carboxylate; Parthenolide derivative; Germacranolide sesquiterpene lactone ester; 92356-80-4; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.