Description

5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9,9a-bis(acetyloxy)-1,1a,1b,2,4a,7a,7b,8,9,9a-decahydro-2,4a,7b-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, [1aR-(1aalpha,1bbeta,2beta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)]- is a complex, high-purity diterpenoid derivative with a unique cyclopropabenzazulene core structure. This compound is valued as a critical advanced pharmaceutical intermediate and a versatile scaffold for synthetic organic chemistry research. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex natural product analogs and potential drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Organic Synthesis Reference Standard: Serves as a high-purity standard for analytical method development and reaction pathway studies.
• Biochemical Research: Potential use in probing biological pathways and enzyme interactions due to its intricate polycyclic structure.
• Fine Chemical Production: Intermediate for the manufacture of specialty chemicals requiring a sophisticated diterpenoid framework.

Basic Information

Product Name	5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9,9a-bis(acetyloxy)-1,1a,1b,2,4a,7a,7b,8,9,9a-decahydro-2,4a,7b-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, [1aR-(1aalpha,1bbeta,2beta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)]-
CAS No.	77573-19-4
Molecular Formula	C26H34O9
Molecular Weight	490.54 g/mol
Synonyms	Taxuspine X; Taxuspine X (Taxus chinensis); 9,9a-Diacetoxy-2,4a,7b-trihydroxy-3-hydroxymethyl-1,1,6,8-tetramethyl-1,1a,1b,2,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one; [1aR-(1aalpha,1bbeta,2beta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)]-9,9a-Bis(acetyloxy)-1,1a,1b,2,4a,7a,7b,8,9,9a-decahydro-2,4a,7b-trihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent GMP-grade guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity, NMR for structural confirmation, and MS for identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.