Description

(5R,5aα)-5α,8,8aβ,9α-Tetrahydro-9β-[[4-O,6-O-(o-hydroxybenzylidene)-β-D-glucopyranosyl]oxy]-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one is a complex, high-purity glycosylated naphthofurandioxole derivative, representing a sophisticated chemical entity for advanced research and development. Its intricate molecular architecture, featuring a fused ring system and a protected glucopyranosyl moiety, makes it a critical intermediate or reference standard in specialized organic synthesis. This compound is primarily sought by pharmaceutical R&D laboratories and academic research institutions focused on medicinal chemistry and natural product synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.
• Reference Standard: Used for analytical method development, validation, and quality control in laboratories studying complex organic molecules.
• Medicinal Chemistry Research: A valuable probe for structure-activity relationship (SAR) studies due to its unique polycyclic framework and functional groups.
• Natural Product Analogue Synthesis: Acts as a synthetic target or precursor for creating analogues of biologically active natural products.
• Biochemical Research: Potential use in studying enzyme interactions or as a ligand in biochemical assays.
• Advanced Material Science: Exploration of its properties for potential applications in specialized organic electronic materials.

Basic Information

Product Name	(5R,5aα)-5α,8,8aβ,9α-Tetrahydro-9β-[[4-O,6-O-(o-hydroxybenzylidene)-β-D-glucopyranosyl]oxy]-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CAS No.	73839-75-5
Molecular Formula	C₃₉H₃₈O₁₅
Molecular Weight	746.71 g/mol
Synonyms	9-[(4,6-O-[(2-Hydroxybenzylidene)]-β-D-glucopyranosyl)oxy]-5-(3,4,5-trimethoxyphenyl)-5,5a,8,8a,9,9a-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Podophyllotoxin 4,6-O-(salicylidene)-β-D-glucoside derivative; Salicylidene-protected glucosyl podophyllotoxin analogue; CAS 73839-75-5; 73839-75-5; Glucosylated naphthofurandioxole derivative.
EINECS	Contact for details

Quality Control

Every batch of our high-purity chemical intermediates is produced and tested under a strict quality management system. Standard quality control includes comprehensive analysis via HPLC, NMR, and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support cGMP-compliant manufacturing for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.