Description

1H-Indole-2-Carboxylic Acid, 5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex indole-pyrone hybrid structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily required by R&D and process development teams in the pharmaceutical and biotechnology industries for the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex, target-specific drug molecules, particularly in medicinal chemistry research.
• API Development: Used in the research and process development stages for creating new Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Serves as a precursor or reference standard in biochemical assays and pharmacological studies.
• Organic Synthesis: Employed in advanced organic synthesis for constructing complex heterocyclic frameworks.
• Contract Manufacturing (CMO): Supplied to Contract Manufacturing Organizations for the production of clinical trial materials or niche commercial APIs.

Basic Information

Product Name	1H-Indole-2-Carboxylic Acid, 5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-, Ethyl Ester
CAS No.	2212021-77-5
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	Ethyl 5-[(4S)-Tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indole-2-carboxylate; (4S)-5-(2,2-Dimethyltetrahydro-2H-pyran-4-yl)-1H-indole-2-carboxylic Acid Ethyl Ester; 5-[(4S)-2,2-Dimethyltetrahydropyran-4-yl]-1H-indole-2-carboxylic Acid Ethyl Ester; 5-[(4S)-2,2-Dimethyl-3,4,5,6-tetrahydro-2H-pyran-4-yl]indole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 5-[(4S)-2,2-dimethyltetrahydro-2H-pyran-4-yl]-, ethyl ester; CAS 2212021-77-5.
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carboxylic Acid, 5-[(4S)-Tetrahydro-2,2-Dimethyl-2H-Pyran-4-Yl]-, Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with specifications that can meet ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.