Description

O-[4,6-Di-O-acetyl-2-(acetylamino)-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester is a sophisticated, fully protected glycopeptide building block critical for advanced organic synthesis. This compound is engineered to provide exceptional control and efficiency in the solid-phase and solution-phase synthesis of complex oligosaccharides and glycoconjugates. It is an essential raw material for researchers and manufacturers in pharmaceutical development, particularly for creating novel glycoprotein-based therapeutics, vaccines, and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of glycosylated peptides and glycoproteins.
• Glycoconjugate Vaccine Development: Used in the research and production of carbohydrate-based antigens for next-generation vaccines.
• Glycoprotein Mimetics: Serves as a building block for creating stable mimics of natural glycoproteins for drug discovery.
• Chemical Biology Probes: Enables the synthesis of labeled glycopeptides for studying protein-glycan interactions and cellular processes.
• Oligosaccharide Assembly: A crucial component in the convergent synthesis of complex, biologically active oligosaccharides.
• Pharmaceutical Intermediate: A high-purity starting material for the GMP-compliant manufacture of active pharmaceutical ingredients (APIs) with carbohydrate motifs.

Basic Information

Item	Details
Product Name	O-[4,6-Di-O-acetyl-2-(acetylamino)-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester
CAS No.	658072-67-4
Molecular Formula	C53H64N2O22
Molecular Weight	1081.07 g/mol
Synonyms	Fmoc-Ser(tBu)-[Ac4Galβ1-3(Ac)2GalNAcα]-OH; Fmoc-L-Ser(tBu)-[Ac4Galβ1-3(Ac)2α-D-GalNAc]-OH; Glycopeptide Building Block (Ac4Galβ1-3Ac2α-GalNAc); Fmoc-Ser(tBu)-Ac4Galβ(1-3)Ac2α-GalNAc; O-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1→3)-O-(2-acetamido-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine tert-butyl ester; Protected T-Antigen (Galβ1-3GalNAc) Building Block; Fmoc-Ser(tBu)-Tn antigen derivative (protected).
EINECS	Contact for details

Quality Control

Every batch of this advanced building block is produced and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles via validated analytical methods (HPLC, NMR, MS). Our quality commitment ensures the material meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.