Description

(E)-4-Hydroxy-2-methyl-2-butenoic acid (1aR,4E,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl ester CAS NO 57718-81-7 is a high-purity, complex organic ester of significant interest in advanced chemical synthesis. This compound serves as a critical chiral building block and key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its unique stereochemical framework.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of complex drug molecules, particularly for oncology and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides with specific stereochemical activity.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex natural product analogs and specialty polymers.
• Academic & R&D: A valuable compound for methodological studies in asymmetric synthesis and total synthesis projects.
• Process Chemistry Development: Employed in scaling up synthetic routes for novel chemical entities under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(E)-4-Hydroxy-2-methyl-2-butenoic acid (1aR,4E,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl ester
CAS No.	57718-81-7
Molecular Formula	C₂₀H₂₆O₆
Molecular Weight	362.42 g/mol
Synonyms	4-Hydroxy-2-methyl-2-butenoic acid (1aR,4E,7R,7aR,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-1a,5-dimethyl-8-methylene-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl ester; (E)-4-Hydroxy-2-methyl-2-butenoic acid artemisinin ester; Tiglic acid artemisinin derivative; Artemisinin tiglate; 57718-81-7; Artemisinin (E)-4-hydroxy-2-methyl-2-butenoate; Artemisinin α-methyltiglate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under GMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.