Description

Madecassic Acid CAS NO 18449-41-7 is a pentacyclic triterpenoid compound, a key bioactive constituent derived from the medicinal herb *Centella asiatica*. This high-purity phytochemical is valued for its significant biological activity and serves as a critical reference standard and active ingredient. It is essential for manufacturers and researchers in the pharmaceutical, cosmetic, and nutraceutical industries seeking consistent, high-quality botanical extracts for product development and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Madecassic Acid in herbal extracts and finished products via HPLC and LC-MS analysis.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key starting material or intermediate in the synthesis of novel triterpenoid-based drugs targeting inflammation and tissue repair.
• Cosmetic & Skincare Actives: Incorporated into advanced formulations for anti-aging, wound healing, and scar reduction creams and serums due to its collagen-stimulating properties.
• Nutraceutical & Dietary Supplements: Used as a standardized marker compound in high-quality *Centella asiatica* (Gotu Kola) extracts for cognitive and vascular health supplements.
• Biomedical Research: Employed in *in vitro* and *in vivo* studies to investigate mechanisms of action related to antioxidant, anti-inflammatory, and neuroprotective effects.
• Quality Control & Assurance: Essential for analytical laboratories to validate methods, calibrate equipment, and ensure batch-to-batch consistency of raw botanical materials.

Basic Information

Product Name	Madecassic Acid
CAS No.	18449-41-7
Molecular Formula	C30H48O6
Molecular Weight	504.70 g/mol
Synonyms	6-Hydroxyasiatic acid; Brahmic acid; (1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-1H-picene-4a-carboxylic acid; Madecassic acid; 3β,6β,23-Trihydroxyurs-12-en-28-oic acid; NSC 169916; Triterpene acid from Centella asiatica
EINECS	Contact for details

Quality Control

Our Madecassic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, residual solvents, and heavy metals are available upon request. We support compliance with relevant pharmacopeial guidelines (e.g., USP, EP) for botanical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals (as Pb)	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.