Description

(1aR,4E,9S,10R,10aR,13aS,14aR)-2,3,6,7,8,9,10,10a,13,13a,14,14a-Dodecahydro-10-hydroxy-1a,5,9-trimethyl-13-methyleneoxireno[4,5]cyclotetradeca[1,2-b]furan-12(1aH)-one is a high-purity, complex sesquiterpene lactone derivative valued for its unique oxireno-fused cyclotetradecane structure. This compound serves as a critical advanced pharmaceutical intermediate and a versatile scaffold for synthetic organic chemistry research. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel anti-inflammatory and anticancer drug candidates.
• Agrochemical Research: Used as a precursor in developing new generation plant growth regulators or biopesticides.
• Organic Synthesis: Serves as a complex chiral template for total synthesis projects and methodology development.
• Biochemical Research: Investigated for its potential biological activity and structure-activity relationship (SAR) studies.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Details
Product Name	(1aR,4E,9S,10R,10aR,13aS,14aR)-2,3,6,7,8,9,10,10a,13,13a,14,14a-Dodecahydro-10-hydroxy-1a,5,9-trimethyl-13-methyleneoxireno[4,5]cyclotetradeca[1,2-b]furan-12(1aH)-one
CAS No.	52239-68-6
Molecular Formula	C20H28O4
Molecular Weight	332.43 g/mol
Synonyms	8-Epi-Grosheimin; 8-Epigrosheimin; (1aR,4E,9S,10R,10aR,13aS,14aR)-Dodecahydro-10-hydroxy-1a,5,9-trimethyl-13-methylene-7-oxo-4,8-epoxy-1H-cyclopenta[4,5]cyclotetradeca[1,2-b]furan; Grosheimin derivative; Sesquiterpene lactone derivative; Oxireno[4,5]cyclotetradeca[1,2-b]furan-12(1aH)-one derivative
EINECS	Contact for details

Quality Control

Our (1aR,4E,9S,10R,10aR,13aS,14aR)-2,3,6,7,8,9,10,10a,13,13a,14,14a-Dodecahydro-10-hydroxy-1a,5,9-trimethyl-13-methyleneoxireno[4,5]cyclotetradeca[1,2-b]furan-12(1aH)-one is produced under strict quality management systems. Every batch undergoes comprehensive analytical characterization including HPLC, NMR, and MS to ensure structural identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.