Description

(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring indolinone and pyrrole motifs, makes it a critical intermediate for synthesizing targeted bioactive molecules. This compound is essential for medicinal chemists and R&D teams in the pharmaceutical and biotechnology sectors working on novel therapeutic agents, particularly in oncology and inflammation.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, especially kinase inhibitors and receptor antagonists.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its defined stereochemistry and functional groups.
• Biochemical Tool Compound: Employed in high-throughput screening (HTS) assays and target validation studies in academic and industrial research laboratories.
• Pre-clinical Development: Utilized in the development and scale-up of active pharmaceutical ingredients (APIs) for pre-clinical and clinical trial materials.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for client-specific research projects.

Basic Information

Product Name	(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
CAS No.	477575-56-7
Molecular Formula	C32H32Cl2N4O4S
Molecular Weight	639.59 g/mol
Synonyms	477575-56-7; (2R)-1-({5-[(Z)-({5-[(2,6-Dichlorobenzyl)sulfonyl]-2-oxo-2,3-dihydro-1H-indol-3-ylidene})methyl]-2,4-dimethyl-1H-pyrrol-3-yl}carbonyl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine; (R)-1-((5-((Z)-((5-((2,6-Dichlorobenzyl)sulfonyl)-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrol-3-yl)carbonyl)-2-(pyrrolidin-1-ylmethyl)pyrrolidine; UNII-Contact for details; Sunitinib related compound; Indolinone-pyrrole derivative; Chiral pyrrolidine sulfonamide.
EINECS	Contact for details

Quality Control

Our (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine is manufactured under strict GMP-like conditions for research use, ensuring traceability and batch-to-batch consistency. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our rigorous quality testing utilizes advanced analytical techniques including HPLC, NMR, and MS to confirm identity and meet the stringent specifications required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.