Description

(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE is a complex, high-purity chiral indole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) or a key building block for synthesizing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D organizations and contract research and manufacturing services (CRAMS) companies engaged in the discovery of new chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel, high-value active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Protease Inhibitor Research: Used as a core scaffold or precursor in the development of protease inhibitors, leveraging its complex sulfonamide and indole structure.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and hit-to-lead optimization programs due to its defined stereochemistry and multiple functional groups.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Custom Synthesis & CRAMS: A critical material for contract research, development, and manufacturing organizations offering specialized synthesis services to the global pharmaceutical industry.

Basic Information

Item	Detail
Product Name	(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE
CAS No.	439687-69-1
Molecular Formula	C30H32ClN3O8S
Molecular Weight	630.11 g/mol
Synonyms	N-[(2S,4R)-1-[(1R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxypyrrolidin-2-yl]-N,N-dimethylformamide; (2S,4R)-1-[(1R)-5-Chloro-1-(2,4-dimethoxybenzenesulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxypyrrolidine-2-carboxylic acid dimethylamide; CAS 439687-69-1; UNII-9J8K4A8U5C; 9J8K4A8U5C; Aprepitant Intermediate Derivative; Indole-3-carboxamide derivative
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support cGMP compliance for advanced intermediates intended for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.