Description

(2S,10aα,11aα,12R)-2,3,4a,5,6,7,8,9,10,10a,11,11a-Dodecahydro-2,4aβ,7β,12-tetrahydroxy-3,3,7-trimethyl-11-methylene-5aβ,8β-methano-5aH-cyclohepta[b]naphthalen-4(1H)-one is a complex, high-purity diterpenoid compound of significant interest in advanced organic synthesis and pharmaceutical research. Its intricate polycyclic structure with multiple stereocenters makes it a valuable chiral building block and intermediate for developing novel therapeutic agents. This compound is primarily sought by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex natural product derivatives and specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex diterpenoid natural products and their analogs.
• Biochemical Research: Employed in studies investigating biological pathways and enzyme interactions involving diterpenoid structures.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Process Chemistry Development: Utilized in the development and optimization of scalable synthetic routes for advanced pharmaceutical intermediates.

Basic Information

Product Name	(2S,10aα,11aα,12R)-2,3,4a,5,6,7,8,9,10,10a,11,11a-Dodecahydro-2,4aβ,7β,12-tetrahydroxy-3,3,7-trimethyl-11-methylene-5aβ,8β-methano-5aH-cyclohepta[b]naphthalen-4(1H)-one
CAS No.	38733-36-7
Molecular Formula	C20H30O5
Molecular Weight	350.45 g/mol
Synonyms	Gibberellin A4; GA4; Gibberellin A4 (GA4); (2S,10aα,11aα,12R)-2,3,4a,5,6,7,8,9,10,10a,11,11a-Dodecahydro-2,4aβ,7β,12-tetrahydroxy-3,3,7-trimethyl-11-methylene-5aβ,8β-methano-5aH-cyclohepta[b]naphthalen-4(1H)-one; 2,4a,7,12-Tetrahydroxy-3,3,7-trimethyl-11-methylene-5a,8-methano-5aH-cyclohepta[b]naphthalene-4(1H)-one, (2S,4aR,5aR,8R,10aS,10bR)-decahydro-; 1H-5a,8-Methanocyclohepta[b]naphthalen-4(1H)-one, 2,3,4a,5,6,7,8,9,10,10a,11,11a-dodecahydro-2,4a,7,12-tetrahydroxy-3,3,7-trimethyl-11-methylene-, (2S,4aR,5aR,8R,10aS,10bR)-
EINECS	Contact for details

Quality Control

Our Gibberellin A4 (GA4) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm stereochemical integrity, and spectroscopic identification (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and advanced synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.