Description

2-Methylpropionic acid [(3aR,4R,6R,7S,9R,11aR)-2,3,3a,4,5,6,7,8,9,11a-decahydro-7,9-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl] ester is a high-purity, complex organic ester derivative of a sesquiterpene lactone core. This specialized compound serves as a critical advanced intermediate in the synthesis of complex bioactive molecules, offering a unique stereochemical framework for further chemical elaboration. It is primarily required by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly in anti-inflammatory or oncology-related pathways.
• Synthetic Chemistry Research: Used in academic and industrial laboratories for methodological studies in complex molecule synthesis, including stereoselective transformations.
• Natural Product Analog Synthesis: Serves as a starting point or intermediate for synthesizing analogs of sesquiterpene lactone natural products to explore structure-activity relationships.
• Bioconjugation & Probe Development: The ester functionality and complex core can be utilized to create specialized chemical probes or conjugates for biological studies.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, low-volume specialty chemicals for advanced material or agrochemical applications.

Basic Information

Product Name	2-Methylpropionic acid [(3aR,4R,6R,7S,9R,11aR)-2,3,3a,4,5,6,7,8,9,11a-decahydro-7,9-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl] ester
CAS No.	34367-14-1
Molecular Formula	C20H28O7
Molecular Weight	380.43 g/mol
Synonyms	Isobutyric acid, (3aR,4R,6R,7S,9R,11aR)-2,3,3a,4,5,6,7,8,9,11a-decahydro-7,9-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester; Parthenolide 4-Isobutyrate; 4-O-Isobutyrylparthenolide; 4β-Isobutyryloxyparthenolide; Isobutyrylparthenolide; NSC 106572; (4R,6R,7S,9R,11aR)-4-(2-Methylpropanoyloxy)-6,10-dimethyl-3-methylidene-2-oxo-3a,4,5,6,7,8,9,11a-octahydrocyclodeca[b]furan-7,9-diol
EINECS	Contact for details

Quality Control

Our 2-Methylpropionic acid [(3aR,4R,6R,7S,9R,11aR)-2,3,3a,4,5,6,7,8,9,11a-decahydro-7,9-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl] ester is produced under a strict quality management system. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, chiral methods for stereochemical confirmation, and NMR/IR for structural identity, ensuring it meets the exacting standards for advanced synthetic intermediates. Certificates of Analysis (COA) with full chromatographic and spectroscopic data are provided to guarantee traceability and support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (under refrigeration) for long-term stability. The container should be kept in a cool, dry, and well-ventilated area. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.