Description

1H-Isoindol-1-one, 6-[(1R)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)- is a sophisticated chiral organic compound featuring a complex molecular architecture that combines isoindolinone, fluorinated pyrrolidine, oxetane, and triazole motifs. This compound is of significant interest for its potential as a high-value pharmaceutical intermediate or active pharmaceutical ingredient (API) precursor, particularly in the development of targeted therapies. It is primarily sought by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel small-molecule drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique stereochemistry and functional group diversity.
• Process Development & Scale-up: Employed in route scouting, process optimization, and the production of batches for non-clinical and clinical studies.
• Biochemical Probe Development: Potential use in creating tool compounds for investigating specific biological pathways and target validation.
• Custom Synthesis: Supplied for bespoke chemical synthesis projects requiring advanced chiral molecules with fluorinated and heterocyclic components.

Basic Information

Product Name	1H-Isoindol-1-one, 6-[(1R)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)-
CAS No.	2368840-66-6
Molecular Formula	C30H30F4N6O2
Molecular Weight	582.60 g/mol
Synonyms	(2R)-2-[3-[3-[(4-Methyl-4H-1,2,4-triazol-3-yl)methyl]oxetan-3-yl]phenyl]-6-[(1R)-1-[(3S)-3-fluoropyrrolidin-1-yl]ethyl]-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one; CAS 2368840-66-6; 6-[(1R)-1-[(3S)-3-Fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)-1H-isoindol-1-one; 1H-Isoindol-1-one, 6-[(1R)-1-[(3S)-3-fluoro-1-pyrrolidinyl]ethyl]-2,3-dihydro-2-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-4-(trifluoromethyl)-; 2368840-66-6
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.