Description

2-Thiophenecarboxamide, 5-(difluoromethyl)-N-[1-[[(2S)-1-(1-oxo-2-propen-1-yl)-2-pyrrolidinyl]methyl]-5-[[[(1S)-1,2,2-trimethylpropyl]amino]methyl]-1H-benzimidazol-2-yl]- is a sophisticated, high-purity organic compound featuring a complex molecular architecture designed for advanced applications. This compound matters as a key pharmaceutical intermediate or active research chemical in the development of novel therapeutics, particularly in oncology and targeted drug discovery. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) engaged in cutting-edge medicinal chemistry and pre-clinical studies.

Application

This specialized chemical serves as a critical building block in advanced synthetic chemistry. Its primary and inferred applications include:

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates targeting specific enzymes or receptors.
• Protease Inhibitor Development: The structural motifs suggest potential application in the design and synthesis of protease inhibitors, a major class of therapeutic agents.
• Bioconjugation & Probe Synthesis: The reactive acrylamide moiety allows for use in creating chemical probes or antibody-drug conjugates (ADCs) for diagnostic or therapeutic purposes.
• Chemical Biology Tool: Employed in the development of activity-based probes (ABPs) to study enzyme function and mechanism in complex biological systems.
• Custom Synthesis & Scale-Up: Sourced by fine chemical manufacturers for custom synthesis projects and process development for clinical trial material supply.

Basic Information

Product Name	2-Thiophenecarboxamide, 5-(difluoromethyl)-N-[1-[[(2S)-1-(1-oxo-2-propen-1-yl)-2-pyrrolidinyl]methyl]-5-[[[(1S)-1,2,2-trimethylpropyl]amino]methyl]-1H-benzimidazol-2-yl]-
CAS No.	2227198-84-5
Molecular Formula	C27H33F2N5O2S
Molecular Weight	529.65 g/mol
Synonyms	5-(Difluoromethyl)-N-[1-[[(2S)-1-(1-oxo-2-propen-1-yl)-2-pyrrolidinyl]methyl]-5-[[[(1S)-1,2,2-trimethylpropyl]amino]methyl]-1H-benzimidazol-2-yl]-2-thiophenecarboxamide; (S)-5-((S)-1,2,2-Trimethylpropylamino)methyl)-1-((S)-1-acryloylpyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-2-yl)-5-(difluoromethyl)thiophene-2-carboxamide; 2227198-84-5; A potential proteasome inhibitor intermediate; Benzimidazole-thiophene carboxamide derivative.
EINECS	Contact for details

Quality Control

Supplied as a high-purity research-grade chemical, this product undergoes rigorous analytical characterization to ensure batch-to-batch consistency and identity. Our quality assurance protocol includes comprehensive testing via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and relevant physicochemical data. Production and handling follow cGMP principles where applicable to support pre-clinical and early-phase development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a cool, dry, and well-ventilated place. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.