Description

(S)-(-)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propanamine is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it serves as a critical building block for the production of enantiomerically pure active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and high-value chemical products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly those targeting the central nervous system.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides for enhanced efficacy and environmental safety.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in asymmetric synthesis to induce stereoselectivity.
• Academic & Industrial R&D: Serves as a valuable reference standard and starting material for novel chemical entity discovery in medicinal chemistry.
• Fine Chemical Production: Integral to the manufacture of complex, high-value specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	(S)-(-)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propanamine
CAS No.	132335-44-5
Molecular Formula	C9H15NOS
Molecular Weight	185.29 g/mol
Synonyms	(S)-(-)-Duloxetine Intermediate; (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol; (S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propylamine; (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine; (S)-3-Hydroxy-N,N-dimethyl-3-(2-thienyl)propan-1-amine; LY248686; Thiophene propanamine derivative
EINECS	Contact for details

Quality Control

Our (S)-(-)-N,n-Dimethyl-3-Hydroxy-3-(2-Thienyl)Propanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.