Description

5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-, 1,1-dimethylethyl ester, (4S)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex target molecules for preclinical and clinical trials.
• Biochemical Research: Potential use as a tool compound or probe for investigating specific biological pathways and enzyme interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production.

Basic Information

Item	Detail
Product Name	5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-, 1,1-dimethylethyl ester, (4S)-
CAS No.	2212022-55-2
Molecular Formula	C₃₂H₃₂F₂N₆O₄
Molecular Weight	602.64 g/mol
Synonyms	(4S)-tert-Butyl 2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxoimidazolidin-1-yl]-4-methyl-5,6-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxylate; (4S)-1,1-Dimethylethyl 2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; UNII-9V7P8S2F1F; 9V7P8S2F1F; tert-Butyl (4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxoimidazolidin-1-yl]-4-methyl-4,6-dihydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports development under cGMP guidelines for clinical trial material supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. For long-term storage, consider storing under nitrogen or argon in a desiccator.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.