Description

β-Alanine, N-[6-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-1-oxohexyl]-N-2-propyn-1-yl-, 2,5-dioxo-1-pyrrolidinyl ester, rel- is a sophisticated, high-purity chemical building block designed for advanced synthetic applications. This compound is valued for its unique molecular architecture, which incorporates a reactive N-hydroxysuccinimide (NHS) ester group and an alkyne handle, enabling efficient and selective bioconjugation and polymer modification strategies. It is primarily utilized by research institutions and pharmaceutical development teams engaged in creating novel peptide conjugates, targeted drug delivery systems, and functionalized biomaterials.

Application

• Bioconjugation Reagent: Used for the covalent attachment of peptides, proteins, or other biomolecules to surfaces, polymers, or carrier molecules via its NHS ester and alkyne functional groups.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs).
• Polymer Functionalization: Enables the introduction of bio-recognition elements or click-chemistry sites into polymer backbones for advanced material science applications.
• Proteomics Research: Employed in the development of chemical probes and affinity tags for studying protein-protein interactions and cellular pathways.
• Diagnostic Reagent Synthesis: Used in the manufacture of components for immunoassays and other diagnostic platforms requiring stable, site-specific labeling.
• Click Chemistry Substrate: The terminal alkyne group allows for participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of modern bioorthogonal chemistry.

Basic Information

Item	Details
Product Name	β-Alanine, N-[6-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-1-oxohexyl]-N-2-propyn-1-yl-, 2,5-dioxo-1-pyrrolidinyl ester, rel-
CAS No.	2210266-91-2
Molecular Formula	C23H25N3O7
Molecular Weight	455.46 g/mol
Synonyms	rel-β-Alanine, N-[6-[(3aR,4R,7S,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-1-oxohexyl]-N-2-propyn-1-yl-, 2,5-dioxo-1-pyrrolidinyl ester; N-Propynyl-N-(6-(1,3-dioxo-4,7-methanoisoindol-2(3aH,4H,7H,7aH)-yl)-1-oxohexyl)-β-alanine N-hydroxysuccinimide ester; NHS-PEG5-alkyne derivative; Alkyne-PEG5-NHS ester; Propargyl-PEG5-NHS ester; 5k-PEG-Alkyne-NHS; Click Chemistry Reagent 2210266-91-2
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is manufactured under strict quality control protocols in facilities adhering to cGMP (current Good Manufacturing Practice) standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and the NHS ester group is susceptible to hydrolysis. For long-term storage, keep desiccated under an argon or nitrogen atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.