Description

2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-6-[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]- is a sophisticated, high-purity nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. Its value lies in enabling the precise and scalable production of modified DNA/RNA sequences for advanced research and therapeutic applications. This compound is essential for biotechnology, pharmaceutical R&D, and diagnostic developers requiring reliable, high-quality raw materials for antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer in solid-phase automated DNA/RNA synthesizers.
• Therapeutic Nucleic Acid Development: For the research and production of antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) therapeutics.
• Diagnostic Probe Manufacture: Used in creating labeled and modified probes for genetic testing, PCR, and microarray technologies.
• Academic & Industrial R&D: A vital reagent in molecular biology and biochemistry laboratories for studying gene function and regulation.
• Synthesis of Modified Nucleosides: Enables the incorporation of specific, protected functionalities into synthetic oligonucleotide chains.
• Pre-clinical & Process Development: Supports scale-up and optimization of synthesis protocols for Good Manufacturing Practice (GMP) production.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-6-[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-
CAS No.	2172373-55-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-Methyluridine Phosphoramidite; 2'-O-Me-U Phosphoramidite; DMT-2'-O-methyluridine-CE Phosphoramidite; 5'-DMT-2'-O-methyluridine, 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 2'-O-Methyl-5'-O-(4,4'-dimethoxytrityl)uridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl (diisopropylamino)phosphoramidite]
EINECS	Contact for details

Quality Control

Our nucleoside phosphoramidites are manufactured under strict quality controls to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and moisture content, supporting compliance with ISO 9001 standards and the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.