Description

5,8,11-Trioxa-2,14-diazaheptadecanoic acid, 17-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-15-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, rel- is a sophisticated bifunctional chemical building block designed for advanced organic synthesis. This compound is valued for its unique molecular architecture, incorporating a strained bicyclic alkyne and a maleimide group, which enables highly specific and efficient conjugation chemistries, such as strain-promoted azide-alkyne cycloaddition (SPAAC). It is primarily utilized by researchers and process chemists in the pharmaceutical and bioconjugation sectors for the development of novel therapeutics, diagnostic probes, and complex biomolecular conjugates.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, peptides, and oligonucleotides via its reactive maleimide and cyclooctyne moieties.
• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of targeted drug delivery systems and antibody-drug conjugates (ADCs).
• Chemical Probe Synthesis: Used to create activity-based probes for studying enzyme function and biomolecular interactions in chemical biology.
• Materials Science: Enables the functionalization of surfaces, nanoparticles, and polymers with bioactive ligands under mild, copper-free click chemistry conditions.
• Diagnostic Development: Integral for constructing sensitive immunoassay components and imaging agents for in vitro and in vivo diagnostics.

Basic Information

Product Name	5,8,11-Trioxa-2,14-diazaheptadecanoic acid, 17-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-15-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, rel-
CAS No.	2141976-33-0
Molecular Formula	C28H35N3O9
Molecular Weight	557.60 g/mol
Synonyms	rel-(1R,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-15-oxo-5,8,11-trioxa-2,14-diazaheptadecanoate; BCN-PEG4-Maleimide; Maleimide-PEG4-BCN; BCN-PEG4-Mal; BCN-PEG4-Maleimide; BCN-PEG4-NHS ester analog; Cyclooctyne-PEG4-Maleimide; DBCO-PEG4-Maleimide analog (structural isomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, impurities, and other critical parameters are available upon request. We adhere to a quality management system to support research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.