Description

5H-Pyrrolo3,2-dpyrimidine, 7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-4-methoxy-5-2-(trimethylsilyl)ethoxymethyl- is a sophisticated nucleoside analog intermediate, specifically designed for advanced pharmaceutical synthesis. This compound is critical for medicinal chemistry research and development, particularly in the creation of novel antiviral and anticancer therapeutics. It is an essential building block for pharmaceutical companies, biotechnology research institutions, and advanced contract development and manufacturing organizations (CDMOs) engaged in cutting-edge drug discovery programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Antiviral Drug Development: Serves as a critical scaffold for research into novel antiviral agents targeting viral polymerases.
• Oncology Research: Used in the development of targeted cancer therapies, including kinase inhibitors and other small molecule drugs.
• Medicinal Chemistry: A valuable building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial-scale manufacturing of specialty pharmaceuticals.
• Bioconjugation & Prodrug Synthesis: The protected functional groups make it suitable for creating prodrugs or bioconjugates to enhance drug delivery and pharmacokinetics.

Basic Information

Item	Details
Product Name	5H-Pyrrolo3,2-dpyrimidine, 7-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-4-methoxy-5-2-(trimethylsilyl)ethoxymethyl-
CAS No.	299917-12-7
Molecular Formula	C27H49N3O6Si2
Molecular Weight	575.86 g/mol
Synonyms	7-[(3aS,4S,6R,6aR)-6-[[(tert-Butyldimethylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-4-methoxy-5-[(2-trimethylsilylethoxy)methyl]pyrrolo[3,2-d]pyrimidine; Protected Nucleoside Analog Intermediate; TBDMS/TES Protected Pyrrolopyrimidine; CAS 299917-12-7; Advanced Pharmaceutical Building Block; Nucleoside Mimetic Intermediate.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and isomeric composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with ICH guidelines for impurity profiling and stability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.