Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a sophisticated, high-purity synthetic intermediate characterized by its complex pyrrole-dioxole fused ring system and multiple protected functional groups. This compound is of significant value in advanced organic synthesis, particularly for constructing intricate molecular architectures found in active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, biotechnology, and fine chemical sectors for the development of novel therapeutic agents and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides that require specific stereochemistry and functional group arrays.
• Organic Synthesis Reagent: Serves as a versatile precursor for introducing protected amino and carboxylic acid groups into complex molecules under controlled conditions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of chiral, non-racemic compounds.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for methodological studies and the discovery of new chemical entities.
• Material Science Precursor: Potential use in the synthesis of specialized organic ligands or monomers for advanced polymeric materials.

Basic Information

Item	Details
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	284490-15-9
Molecular Formula	C24H39N2O7Si
Molecular Weight	495.67 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-[4-Amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl]-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-[4-amino-5-(ethoxycarbonyl)-1H-pyrrol-3-yl]-6-[[(tert-butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylate; TBDMS-protected pyrrole-dioxole intermediate; CAS 284490-15-9.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Standard quality assurance includes HPLC for purity determination, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.