Description

2,3-Pyridinediamine, 5-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-N,N,N,N-tetrakis(4-methoxyphenyl)methyl- is a sophisticated, high-purity nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. Its value lies in enabling the precise and efficient incorporation of modified bases into DNA or RNA sequences, which is essential for advanced research and therapeutic development. This compound is primarily needed by biotechnology and pharmaceutical companies engaged in antisense drug discovery, diagnostic probe development, and fundamental nucleic acid research.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Production of research-grade and therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probes: Manufacturing of labeled probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR.
• Apitamer Development: Creation of synthetic nucleic acid libraries for selecting high-affinity binding molecules.
• Basic Biochemical Research: Studying nucleic acid structure, function, and protein interactions with site-specifically modified oligonucleotides.
• Next-Generation Sequencing (NGS): Synthesis of custom primers and adapters with specific modifications.

Basic Information

Product Name	2,3-Pyridinediamine, 5-(3aS,4S,6R,6aR)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-N,N,N,N-tetrakis(4-methoxyphenyl)methyl-
CAS No.	258834-83-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(tert-Butyldimethylsilyl)-2'-deoxy-5-methyluridine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 5-Methyl-dU Phosphoramidite (5'-O-TBDMS); 5-Methyl-2'-deoxyuridine phosphoramidite; dT(Me) Phosphoramidite (TBDMS protected); [5-Methyl-2'-deoxyuridine, 5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]]; Nucleoside Phosphoramidite, 5-Methyl-dU
EINECS	Contact for details

Quality Control

Our nucleoside phosphoramidites are manufactured under strict quality systems to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS analysis, to confirm identity, purity, and reactivity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your GMP or research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and potentially oxidizable nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.