Description

1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6R,6aR)-5-(1,1-dimethylethoxy)carbonyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester is a sophisticated, high-purity chemical intermediate characterized by its complex, multi-functional molecular architecture. This compound is of critical importance in advanced organic synthesis, particularly in the construction of complex pharmacophores and novel molecular scaffolds. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially in medicinal chemistry programs targeting new therapeutic agents.
• Nucleoside/Nucleotide Chemistry: Used in the preparation of modified nucleosides and nucleotides for antiviral or anticancer research, leveraging its protected sugar-like moiety.
• Peptidomimetic Synthesis: Acts as a constrained, non-natural amino acid analog for creating peptidomimetics with enhanced metabolic stability and biological activity.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral synthon due to its defined stereocenters, enabling the stereoselective construction of complex molecules.
• Agrochemical Research: Potential intermediate in the discovery of new, high-value crop protection agents with novel modes of action.

Basic Information

Item	Details
Product Name	1H-Pyrrole-1,2-dicarboxylic acid, 3-amino-4-(3aS,4S,6R,6aR)-5-(1,1-dimethylethoxy)carbonyl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-4H-1,3-dioxolo4,5-cpyrrol-4-yl-, 2-ethyl 1-(phenylmethyl) ester
CAS No.	222631-12-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	3-Amino-4-[(3aS,4S,6R,6aR)-5-(tert-butoxycarbonyl)-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-1H-pyrrole-1,2-dicarboxylic acid 2-ethyl ester 1-benzyl ester; Benzyl 2-ethyl 3-amino-4-[(3aS,4S,6R,6aR)-5-(tert-butoxycarbonyl)-6-[[(tert-butyldimethylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-1H-pyrrole-1,2-dicarboxylate; Protected pyrrole-dicarboxylate intermediate; TBDMS-protected nucleoside analog precursor.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for sensitive synthetic applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development and cGMP-grade production upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This material is light-sensitive (store away from light) and should be handled in a dry, inert environment to preserve stability. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.