Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(cyanomethyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined structure. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), offering researchers and manufacturers a reliable source for complex molecular construction. It is primarily utilized by the pharmaceutical and biotechnology industries for the research and development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry research.
• API Development: Serves as a crucial precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) with specific stereochemical requirements.
• Process Chemistry: Used in route scouting and optimization studies for the efficient and scalable production of target molecules.
• Chemical Biology Research: Employed as a molecular scaffold or probe in the study of biological pathways and target identification.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) specializing in bespoke chemical synthesis.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(cyanomethyl)-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-09-6
Molecular Formula	C21H35NO5Si
Molecular Weight	409.60 g/mol
Synonyms	(3aS,4S,6R,6aR)-4-(Cyanomethyl)-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-5H-1,3-dioxolo[4,5-c]pyrrole-5-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3aS,4S,6R,6aR)-4-(cyanomethyl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; TBDMS-protected pyrrolidine derivative; Advanced chiral pyrrolidine intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.