Description

(6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane hydrochloride (1:4) is a complex, high-purity organic salt designed for advanced research and development. This compound is valued for its sophisticated molecular architecture, which incorporates multiple heterocyclic and spirocyclic motifs, making it a critical intermediate or active pharmaceutical ingredient (API) in targeted therapeutic discovery. It serves the needs of pharmaceutical R&D teams, medicinal chemists, and biotechnology firms engaged in the synthesis of novel drug candidates, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel, high-potency drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, drug-like scaffold.
• Oncology Drug Discovery: Serves as a precursor or core structure for developing targeted cancer therapies, leveraging its benzimidazole and fluorene components.
• Biochemical Probe Development: Utilized in the creation of specialized probes for studying enzyme inhibition or receptor binding mechanisms.
• Preclinical Development: Supplied for formulation studies, pharmacokinetic profiling, and initial toxicology assessments of new chemical entities.
• Contract Research & Manufacturing (CRO/CMO): Sourced by service organizations supporting pharmaceutical clients with custom synthesis and process development.

Basic Information

Product Name	(6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane hydrochloride (1:4)
CAS No.	1499193-67-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-Azaspiro[2.4]heptane, 6-[5-[7-[2-(1R,3S,4S)-2-azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-, hydrochloride (1:4), (6S)-; 1499193-67-7; (6S)-6-[5-[7-[2-(1R,3S,4S)-2-Azabicyclo[2.2.1]hept-3-yl-1H-benzimidazol-6-yl]-9,9-difluoro-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptane tetrahydrochloride; Complex Spirocyclic Benzimidazole-Fluorene Derivative Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and stoichiometry. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a quality management system suitable for supplying materials for non-GMP and GMP-preparative applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Assay (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.