Description

(3R,5R,8S,9S,10S,13S,14S,17R)-9,12,12-trideuterio-17-(2,2-dideuterio-2-hydroxyacetyl)-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one is a high-purity, deuterium-labeled steroid derivative, specifically a deuterated analog of a key cortisol intermediate. This compound is critical for metabolic pathway tracing and pharmacokinetic studies in pharmaceutical research and development. It is primarily used by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced steroid research, drug metabolism analysis, and the development of novel analytical methods.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a stable, non-interfering reference compound for the precise quantification of cortisol and related steroids in biological matrices.
• Metabolic Tracer Studies: Used in in vitro and in vivo research to elucidate the metabolic fate, biotransformation pathways, and enzyme kinetics of corticosteroid drugs.
• Pharmaceutical R&D: A key intermediate or reference material in the development and validation of new steroid-based therapeutics, including anti-inflammatory and hormonal agents.
• Biomarker Research: Facilitates the development of highly sensitive and specific diagnostic assays for endocrine disorders by improving analytical accuracy.
• Stable Isotope Labeling: Provides a deuterium-labeled building block for the synthesis of more complex labeled steroid molecules for advanced research applications.
• Quality Control & Method Development: Employed in analytical laboratories to validate and calibrate instruments (HPLC, GC-MS) for steroid analysis, ensuring regulatory compliance.

Basic Information

Item	Details
Product Name	(3R,5R,8S,9S,10S,13S,14S,17R)-9,12,12-trideuterio-17-(2,2-dideuterio-2-hydroxyacetyl)-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-11-one
CAS No.	1485501-48-1
Molecular Formula	C21H26D5O5
Molecular Weight	Contact for details
Synonyms	9,12,12,21,21-D5-Cortisol; Deuterated Cortisol Intermediate; 11-Deoxycortisol-d5; 17α,21-Dihydroxypregn-4-ene-3,20-dione-9,12,12,21,21-d5; 17-Hydroxy-11-deoxycorticosterone-d5; Reichstein's Substance S-d5; 21-Hydroxy-4-pregnene-3,20-dione-d5; Cortisol-d5 (specifically labeled isomer)
EINECS	Contact for details

Quality Control

Every batch of our deuterated steroid compounds is produced and tested under strict quality management protocols. We employ advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to verify chemical identity, isotopic purity (D-enrichment), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances is provided with each shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation by atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.