Description

Acetic-2,2,2-D3 Acid is a deuterated isotopologue of acetic acid, where the three methyl hydrogens are replaced by deuterium atoms. This isotopic labeling is critical for applications requiring precise molecular tracking and reduced signal interference in spectroscopic analysis. It is an essential reagent for researchers and manufacturers in the pharmaceutical, analytical chemistry, and advanced materials sectors who require high-purity, isotopically-enriched building blocks.

Application

• NMR Spectroscopy: Used as an internal standard or solvent for proton NMR due to the absence of proton signals from the methyl group, providing a clean baseline for analysis.
• Pharmaceutical Research & Development: Serves as a labeled precursor in the synthesis of deuterated drug molecules for metabolic, pharmacokinetic (DMPK), and mechanistic studies.
• Mass Spectrometry (MS): Employed as a standard in quantitative MS methods and for developing calibration curves due to its defined isotopic pattern.
• Organic Synthesis: Acts as a source of a deuterated acetyl or methyl group in the synthesis of complex labeled compounds for research and diagnostic applications.
• Vibrational Spectroscopy: Useful in FT-IR and Raman spectroscopy studies to isolate and assign vibrational modes by isotopic shift.
• Chemical Reaction Mechanism Studies: Utilized to elucidate reaction pathways, including kinetic isotope effect (KIE) studies, by tracing the fate of specific atoms.

Basic Information

Product Name	Acetic-2,2,2-D3 Acid
CAS No.	1112-02-3
Molecular Formula	C₂D₃HO₂
Molecular Weight	63.06 g/mol
Synonyms	Acetic Acid-d3; Deuterated Acetic Acid (methyl-d3); Perdeuterioacetic Acid (methyl-d3); Acetic-d3 Acid; [2H3]-Acetic Acid; CD3COOD; Glacial Acetic Acid-d3; Trideuteroacetic Acid
EINECS	Contact for details

Quality Control

Every batch of Acetic-2,2,2-D3 Acid is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity for sensitive research applications. Our products undergo rigorous quality testing, including NMR and GC-MS, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and strong acid/organic solvent nature, store in a cool, well-ventilated place, away from heat sources and incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C to minimize volatility and maintain stability.

Specification

Item	Specification
Appearance	Colorless liquid
Identification (IR)	Conforms
Isotopic Enrichment (D, min)	99.0 atom % D
Chemical Purity (GC, min)	99.5%
Water Content (KF, max)	0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.