Description

3H-Diazirine-3-D is a deuterated, highly reactive carbene precursor used in photochemical labeling and cross-linking applications. Its value lies in its ability to generate highly reactive carbene species upon photolysis, enabling the study of biomolecular interactions and material surfaces. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise, stable isotopic labeling for mechanistic studies.

Application

• Photoaffinity Labeling: A critical tool in drug discovery for mapping small molecule-protein binding sites and identifying biological targets.
• Biomolecular Cross-linking: Used in structural biology and proteomics to capture transient protein-protein or protein-ligand interactions for analysis.
• Surface Modification & Functionalization: Enables the covalent attachment of functional groups to polymers, nanoparticles, and other material surfaces under mild, light-activated conditions.
• Mechanistic Organic Chemistry Studies: Serves as a versatile carbene source for investigating reaction mechanisms and synthesizing complex organic molecules.
• Isotopic Tracer Applications: The deuterium label allows for tracking and analysis using techniques like mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Basic Information

Product Name	3H-Diazirine-3-D
CAS No.	10310-87-9
Molecular Formula	C2H2D2N2
Molecular Weight	58.08 g/mol
Synonyms	3H-Diazirine-d2; Diaziridine-d2; Deuterated Diazirine; 3H-Diazirine-3,3-d2; Carbene Precursor-d2; Photolabile Cross-linker-d2; 3H-Diazirine (D2); Diazacyclopropene-d2
EINECS	Contact for details

Quality Control

Every batch of 3H-Diazirine-3-D is manufactured and tested under strict quality protocols to ensure high isotopic purity and chemical integrity, critical for sensitive research applications. Our quality assurance includes verification by NMR, Mass Spectrometry, and HPLC to confirm deuterium enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at recommended temperatures between 2°C and 8°C. Due to its highly volatile and light-sensitive nature, minimize exposure to ambient conditions and handle under an inert atmosphere when appropriate.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.