Description

2H-Indol-2-one, 1,3-dihydro-3-[6-(phenylmethoxy)-1,3-benzodioxol-5-yl]-3-[(phenylmethoxy)methyl]-1-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3S)- is a high-purity, chiral synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring indolone, benzodioxole, and trifluoromethyl furan moieties, makes it a critical building block for the synthesis of novel bioactive compounds. This product is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the discovery of new therapeutic agents, particularly in areas requiring sophisticated stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the research and synthesis of potential new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold or building block in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a critical material for scaling up synthetic routes from laboratory to pilot plant scale.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis, catalysis, and drug discovery methodologies.

Basic Information

Product Name	2H-Indol-2-one, 1,3-dihydro-3-[6-(phenylmethoxy)-1,3-benzodioxol-5-yl]-3-[(phenylmethoxy)methyl]-1-[[5-(trifluoromethyl)-2-furanyl]methyl]-, (3S)-
CAS No.	1467104-87-5
Molecular Formula	C36H28F3NO6
Molecular Weight	627.61 g/mol
Synonyms	(3S)-1,3-Dihydro-3-[6-(benzyloxy)-1,3-benzodioxol-5-yl]-3-[(benzyloxy)methyl]-1-[[5-(trifluoromethyl)-2-furanyl]methyl]-2H-indol-2-one; (3S)-3-(6-(Benzyloxy)benzo[d][1,3]dioxol-5-yl)-3-((benzyloxy)methyl)-1-((5-(trifluoromethyl)furan-2-yl)methyl)indolin-2-one; (S)-Indolin-2-one derivative CAS 1467104-87-5; Advanced Pharmaceutical Intermediate 1467104-87-5; Chiral Indolone-Benzodioxole Trifluoromethyl Furan Hybrid
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with ICH guidelines for impurities in drug substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.