Description

4,6,12,19-Tetraazadocosane-1,3,7-tricarboxylic acid, 22-[3-[[[2-[[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl](carboxymethyl)amino]ethyl](carboxymethyl)amino]methyl]-4-hydroxyphenyl]-5,13,20-trioxo-, (3S,7S)- is a sophisticated, high-purity synthetic organic compound featuring a complex polyazamacrocyclic structure with multiple carboxylic acid and phenolic hydroxyl functional groups. This molecular architecture makes it a versatile and highly specific chelating agent, crucial for applications requiring precise metal ion binding and sequestration. It is primarily utilized in advanced pharmaceutical research, diagnostic agent development, and specialized chemical synthesis where its unique coordination properties are essential.

Application

• Pharmaceutical Intermediate: Serves as a critical building block or active chelating moiety in the synthesis of novel therapeutic agents, particularly in oncology and diagnostic imaging.
• Diagnostic Chelator: Used in the development of contrast agents for Magnetic Resonance Imaging (MRI) and other medical imaging techniques due to its strong and selective binding to gadolinium and other lanthanide ions.
• Research Chemical: Employed in academic and industrial R&D for studying metal-ligand interactions, catalysis, and the development of new supramolecular complexes.
• Analytical Reagent: Functions as a selective complexing agent in analytical chemistry for the separation, detection, or quantification of specific metal ions in complex matrices.
• Catalyst Ligand: Acts as a ligand in homogeneous catalysis, where its multidentate nature can stabilize metal catalysts for various organic transformations.
• Specialty Chemical Synthesis: Used in the preparation of advanced materials, such as metal-organic frameworks (MOFs) or functional polymers requiring integrated metal-binding sites.

Basic Information

Item	Details
Product Name	4,6,12,19-Tetraazadocosane-1,3,7-tricarboxylic acid, 22-[3-[[[2-[[[5-(2-carboxyethyl)-2-hydroxyphenyl]methyl](carboxymethyl)amino]ethyl](carboxymethyl)amino]methyl]-4-hydroxyphenyl]-5,13,20-trioxo-, (3S,7S)-
CAS No.	1366302-52-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DOTAGA-tris(tBu-ester); (3S,7S)-DOTAGA-tris(tBu ester); 2,2',2''-(10-((3S,7S)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid) tris(tert-butyl) ester; DOTAGA-tris-tert-butyl ester; Macrocyclic chelator precursor; Gadolinium chelator intermediate; 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid-10-glutaric acid tris(tert-butyl) ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters. Our quality commitment supports its use in cGMP-compliant pharmaceutical development and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% (3S,7S)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.