Description

(1R,3R,5Z)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(diphenylphosphinyl)-1-methylethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]cyclohexanol1 acetate is a highly specialized, advanced pharmaceutical intermediate featuring a complex, multi-chiral structure. This compound is critical for the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in the fields of oncology and endocrinology, where precise stereochemistry is paramount for biological activity. It is an essential building block for research institutions and pharmaceutical manufacturers engaged in the development of novel, high-value therapeutic agents.

Application

• Key Intermediate in Steroid Analog Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex steroid-derived pharmaceuticals.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for the discovery and optimization of new drug candidates targeting hormone receptors.
• API Manufacturing: Employed in the commercial-scale production of specific, high-potency active pharmaceutical ingredients.
• Asymmetric Synthesis: Utilized in chiral synthesis pathways due to its defined stereocenters, enabling the construction of enantiomerically pure compounds.
• Process Chemistry Development: Acts as a standard or reference material for developing and scaling up efficient synthetic routes in process R&D.

Basic Information

Item	Detail
Product Name	(1R,3R,5Z)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1S)-2-(diphenylphosphinyl)-1-methylethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]cyclohexanol1 acetate
CAS No.	1201795-13-2
Molecular Formula	C41H61O3PSi
Molecular Weight	661.0 g/mol
Synonyms	Contact for details
EINECS	Contact for details

Quality Control

Every batch of this high-purity intermediate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We ensure identity, purity, and stereochemical integrity through advanced techniques including NMR, HPLC, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.