Description

2-Chloro-1,3,2-Dioxaphospholane-2-Oxide is a versatile and highly reactive cyclic phosphorus ester chloride, widely recognized as a key intermediate in organophosphorus chemistry. Its primary value lies in its ability to act as a phosphorylating agent, facilitating the efficient synthesis of complex phosphate esters and phosphoramidates under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries, where it is used to create novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide analogs, prodrugs, and other bioactive phosphate-containing molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators that incorporate phosphonate or phosphate ester functionalities.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating flame-retardant polymers, specialty polyphosphoesters, and functionalized materials.
• Ligand & Catalyst Preparation: Employed in the synthesis of chiral phosphine ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new phosphorylation methodologies and organophosphorus compounds.
• Surface Modification: Used to phosphorylate surfaces or materials to alter their wettability, biocompatibility, or adhesion properties.

Basic Information

Product Name	2-Chloro-1,3,2-Dioxaphospholane-2-Oxide
CAS No.	6609-64-9
Molecular Formula	C2H4ClO3P
Molecular Weight	142.48 g/mol
Synonyms	2-Chloro-2-oxo-1,3,2-dioxaphospholane; 2-Chloro-1,3,2-dioxaphospholan-2-one; 2-Chloro-2-oxo-1,3,2-dioxaphospholane; Ethylene chlorophosphite cyclic ester with phosphoric acid; Chloro(2-oxo-1,3,2-dioxaphospholanyl)phosphine oxide; 2-Chloro-2-oxo-1,3,2-dioxaphosphorinane (common misnomer); Phosphonic chloride, cyclic ethylene ester
EINECS	229-562-1

Quality Control

Our 2-Chloro-1,3,2-Dioxaphospholane-2-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration and impurity profiling, to ensure high purity and consistency for sensitive synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and moisture content are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.