Description

(2S,4R)-tert-butyl 4-((7-chloro-4-Methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidine-1-carboxylate is a sophisticated chiral intermediate of significant interest in advanced pharmaceutical synthesis. Its complex, multi-cyclic structure makes it a critical building block for the development of novel therapeutic agents, particularly protease inhibitors. This high-purity compound is essential for research and development organizations and contract manufacturing organizations (CMOs) engaged in cutting-edge drug discovery programs targeting complex diseases.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel protease inhibitors and other biologically active molecules.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in research pipelines.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the complex synthetic routes of investigational new drugs (INDs) and new chemical entities (NCEs).
• Biochemical Research: Employed as a tool compound in enzymatic studies to investigate inhibition mechanisms and binding affinities.
• Contract Manufacturing: Supplied to CMOs and CDMOs for the cGMP production of clinical trial materials and commercial APIs.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic pathways from laboratory to pilot plant scale.

Basic Information

Product Name	(2S,4R)-tert-butyl 4-((7-chloro-4-Methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.	1028252-17-6
Molecular Formula	C30H35ClN4O7S
Molecular Weight	631.14 g/mol
Synonyms	1,1-Dimethylethyl (2S,4R)-4-[[7-chloro-4-methoxy-1-isoquinolinyl]oxy]-2-[[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenyl-1-cyclopropyl]carbonyl]-1-pyrrolidinecarboxylate; BOC-Protected Chloroisoquinoline Vinylcyclopropane Pyrrolidine Derivative; (2S,4R)-1-Boc-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidine; CAS 1028252-17-6; tert-Butyl (2S,4R)-4-((7-chloro-4-methoxyisoquinolin-1-yl)oxy)-2-(((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamoyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the Certificate of Analysis. The container should be kept in a dry, well-ventilated area. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.