Description

1H-BenziMidazole-5-carboxylic acid, 2-[[5-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-indazol-3-yl]aMino]-1-[trans-4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexyl]-, ethyl ester is a sophisticated, multi-functional organic intermediate designed for advanced synthetic chemistry. This compound is of significant value in pharmaceutical research and development, serving as a critical building block for the synthesis of complex bioactive molecules. It is primarily targeted at medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, structurally complex intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and targeted therapy research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for developing new active pharmaceutical ingredients (APIs).
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional degrader molecules.
• Kinase Inhibitor Synthesis: Integral to the construction of heterocyclic cores found in selective kinase inhibitors.
• Chemical Biology Probes: Used to create tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	1H-BenziMidazole-5-carboxylic acid, 2-[[5-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-indazol-3-yl]aMino]-1-[trans-4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexyl]-, ethyl ester
CAS No.	1012104-44-7
Molecular Formula	C36H52BrN5O4Si2
Molecular Weight	763.91 g/mol
Synonyms	Ethyl 2-((5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)amino)-1-(trans-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-1H-benzo[d]imidazole-5-carboxylate; 1H-Benzoimidazole-5-carboxylic acid, 2-[(5-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl)amino]-1-[trans-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-, ethyl ester; CAS 1012104-44-7; Brominated Indazole-Benzimidazole Ester Intermediate; TBDMS/TES Protected Cyclohexyl Benzimidazole Ester; 1012104-44-7; Advanced Pharmaceutical Building Block
EINECS	Contact for details

Quality Control

Our 1H-BenziMidazole-5-carboxylic acid, 2-[[5-broMo-1-[[2-(triMethylsilyl)ethoxy]Methyl]-1H-indazol-3-yl]aMino]-1-[trans-4-[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexyl]-, ethyl ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.