Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyl-6-3-(di-2-propenylamino)phenyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for enabling complex synthetic pathways in modern medicinal chemistry, particularly for the development of targeted therapeutics. It is primarily sought after by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders or oncological pathways.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of new chemical entities (NCEs).
• Asymmetric Synthesis: The defined stereochemistry (3aR,4R,6S,6aS) makes it a valuable chiral synthon for constructing molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protecting Group Strategy: The tert-butyl ester and silyl ether groups are utilized in complex synthetic sequences requiring orthogonal deprotection.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Item	Details
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyl-6-3-(di-2-propenylamino)phenyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	188744-89-0
Molecular Formula	C30H46N2O5Si
Molecular Weight	542.79 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-[(tert-Butyldimethylsilyloxy)methyl]-6-[3-(diallylamino)phenyl]tetrahydro-2,2-dimethyl-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aR,4R,6S,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-6-(3-(diallylamino)phenyl)-2,2-dimethyltetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; CAS 188744-89-0; Advanced Pyrrolidine Intermediate; Chiral Dioxolopyrrole Derivative; TBS-protected amino pyrrole ester.
EINECS	Contact for details

Quality Control

Our cGMP-compliant manufacturing ensures this advanced intermediate meets the stringent requirements of pharmaceutical development. Every batch is characterized by HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all analytical results are provided and can be tailored to support regulatory filings (IND, NDA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and may be incompatible with fluoride/strong alkali. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.