Description

2,3-dihexadecanoyloxypropoxy-[2-[[(2S)-3-methyl-2-[[(2S)-4-methyl-2-[1-[(2R)-2-[[(2S)-2-(2-methylpropoxycarbonylamino)-3-phenyl-propanoyl]amino]-3-naphthalen-2-yl-propanoyl]piperidine-4-carbonyl]oxy-pentanoyl]amino]butanoyl]amino]ethoxy]phosphinic acid is a sophisticated synthetic phospholipid derivative, representing a high-value intermediate in advanced pharmaceutical research. Its complex structure, featuring a phosphinic acid head group and multiple chiral centers, makes it a critical building block for the development of novel drug delivery systems and targeted therapeutics. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on liposomal formulations, prodrug strategies, and next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and prodrugs, particularly for oncology and targeted therapies.
• Lipid-Based Drug Delivery: A functionalized phospholipid component for constructing advanced liposomes, nanoparticles, and other lipid-based carriers to improve drug solubility, stability, and bioavailability.
• Bioconjugation & Prodrug Development: Used to create covalently linked drug-lipid conjugates, enabling targeted drug release and enhanced cellular uptake.
• Biomedical Research: A valuable tool compound in academic and industrial R&D for studying membrane interactions, cell signaling pathways, and novel therapeutic mechanisms.
• Specialty Chemical Synthesis: Serves as a chiral building block for the synthesis of other high-value, structurally complex molecules in fine chemical production.

Basic Information

Product Name	2,3-dihexadecanoyloxypropoxy-[2-[[(2S)-3-methyl-2-[[(2S)-4-methyl-2-[1-[(2R)-2-[[(2S)-2-(2-methylpropoxycarbonylamino)-3-phenyl-propanoyl]amino]-3-naphthalen-2-yl-propanoyl]piperidine-4-carbonyl]oxy-pentanoyl]amino]butanoyl]amino]ethoxy]phosphinic acid
CAS No.	159440-09-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,2-Dipalmitoyl-sn-glycero-3-phospho-L-serine-N-palmitoyl amide derivative; Functionalized phospholipid conjugate; Phosphinic acid lipid derivative; Chiral phospholipid intermediate; CAS 159440-09-2; (2S)-2-[[(2R)-2-[[4-[1-[(2S)-2-[[(2S)-2-[(2-methylpropanoyloxy)formamido]-3-phenylpropanoyl]amino]-3-(naphthalen-2-yl)propanoyl]piperidin-1-yl]-2-oxo-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoic acid derivative; Lipidic prodrug intermediate
EINECS	Contact for details

Quality Control

Every batch of this high-purity synthetic intermediate is manufactured under strict quality management systems to ensure consistency and reliability for critical research and development. Our quality control protocol includes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry to verify identity, chiral purity, and chemical integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.