Description

(αR,βS)-β-(BenzoylaMino)-α-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,1 is a sophisticated, high-purity chiral intermediate featuring a complex, multi-functional molecular architecture. This compound is of critical importance in advanced pharmaceutical synthesis, particularly for constructing complex natural product derivatives and active pharmaceutical ingredients (APIs) with specific stereochemistry. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, where precise stereochemical control is paramount for biological activity and regulatory approval.

Application

• Key chiral intermediate in the multi-step synthesis of complex pharmaceutical agents and natural product analogs.
• Building block for the research and development of new chemical entities (NCEs) in medicinal chemistry programs.
• Precursor in the preparation of stereochemically defined taxane or diterpenoid derivatives for oncology research.
• Critical reagent for process chemistry development and scale-up of target molecules in GMP environments.
• Tool compound for studying structure-activity relationships (SAR) in drug discovery.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(αR,βS)-β-(BenzoylaMino)-α-[[(1,1-diMethylethyl)diMethylsilyl]oxy]-benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,1
CAS No.	156413-61-5
Molecular Formula	C43H51NO9Si
Molecular Weight	754.0 g/mol (approx.)
Synonyms	(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (αR,βS)-β-(Benzoylamino)-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzenepropanoate; Protected Taxol Side Chain Derivative; TBDMS-protected N-benzoyl-3-phenylisoserine Taxol Intermediate; (3R,4S)-1-(tert-Butyldimethylsilyl)-3-(1R,2S)-1-benzamido-2-hydroxy-3-phenylpropionyloxy-4-phenylazetidin-2-one Derivative; β-Lactam Taxol Side Chain Synthon; N-Benzoyl-O-TBDMS-3-phenylisoserine Taxol Precursor; Advanced Paclitaxel Synthesis Intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for pharmaceutical research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and residual solvent levels is provided with every shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (1H & 13C)
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.