Description

(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide is a high-purity synthetic organic compound of significant interest in advanced pharmaceutical research and development. This complex molecule serves as a critical intermediate or reference standard for the study of novel therapeutic agents, particularly in the field of central nervous system (CNS) pharmacology. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in the synthesis and biological evaluation of new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of potential analgesic or neuropharmacological drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in drug discovery pipelines.
• Biochemical Research: Tool compound for in vitro and in vivo studies targeting specific opioid or related G-protein coupled receptors (GPCRs).
• Process Chemistry: Serves as a benchmark for optimizing synthetic routes and scaling up production under current Good Manufacturing Practices (cGMP).
• Metabolite Studies: Used as a precursor or analog in the investigation of drug metabolism and pharmacokinetics (DMPK).

Basic Information

Product Name	(E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
CAS No.	152658-36-1
Molecular Formula	C₃₂H₃₆N₂O₅
Molecular Weight	528.64 g/mol
Synonyms	Buprenorphine metabolite M3; (2E)-N-[(4R,4aS,7S,7aR,12bS)-3-(Cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]-3-(3-furyl)-N-methyl-2-propenamide; Norbuprenorphine-3-glucuronide aglycone derivative; 3-Desmethylbuprenorphine; Buprenorphine analog
EINECS	Contact for details

Quality Control

Our (E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide is manufactured and controlled under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.