Description

R(-)-Methadone Hydrochloride is the pharmacologically active enantiomer of the synthetic opioid agonist methadone. This high-purity chiral compound is critical for research and development in neuropharmacology and for the production of specialized pharmaceutical reference standards. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on opioid receptor studies, pain management research, and forensic analysis.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quality control and assay validation of methadone-based medications and related substances.
• Neuropharmacological Research: Used as a selective tool compound in in vitro and in vivo studies to investigate the mechanisms, binding affinity, and stereospecific effects of opioid agonists at receptor sites.
• Analytical Chemistry: Employed as a high-purity calibrant and system suitability standard in chromatographic methods (HPLC, GC) and spectroscopic analysis for forensic and clinical toxicology.
• Drug Discovery & Development: Acts as a key chiral intermediate or active pharmaceutical ingredient (API) precursor in the development of novel analgesic formulations and addiction treatment therapies.
• Academic & Clinical Studies: Facilitates research into opioid tolerance, dependence, and the pharmacological differentiation of enantiomers in controlled scientific settings.

Basic Information

Product Name	R(-)-Methadone Hydrochloride
CAS No.	125-58-6
Molecular Formula	C21H28ClNO
Molecular Weight	345.91 g/mol
Synonyms	(-)-Methadone Hydrochloride; (R)-(-)-Methadone Hydrochloride; Levomethadone Hydrochloride; (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone Hydrochloride; L-Polamidon Hydrochloride; R(-)-Methadone HCl; Opioid Agonist; CAS 125-58-6
EINECS	204-754-5

Quality Control

Our R(-)-Methadone Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets exacting standards for research and reference use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.