Description

2-(2-(Difluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring difluoromethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for forming carbon-carbon bonds in the synthesis of complex organic molecules, liquid crystals, and OLED materials.
• Material Science Research: Serves as a precursor for creating functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in the development of labeled compounds and probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: An essential raw material for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	2-(2-(Difluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	960067-33-8
Molecular Formula	C₁₃H₁₇BF₂O₃
Molecular Weight	282.08 g/mol
Synonyms	2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(Difluoromethoxy)phenyl)boronic acid pinacol ester; 2-(Difluoromethoxy)phenylboronic acid pinacol ester; [2-(Difluoromethoxyphenyl)]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; Pinacol [2-(difluoromethoxy)phenyl]boronate; 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 960067-33-8
EINECS	Contact for details

Quality Control

Our 2-(2-(Difluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.