Description

4-Hydroxy-Piperidine-3-Carboxylic Acid Methyl Ester is a high-purity, functionalized piperidine derivative that serves as a critical chiral building block and advanced pharmaceutical intermediate. Its unique structure, featuring both a hydroxyl group and a methyl ester on the piperidine ring, makes it a versatile synthon for constructing complex molecules with precise stereochemistry. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Employed in the development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Catalyst and Ligand Development: Utilized in the preparation of chiral ligands for asymmetric catalysis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-Hydroxy-Piperidine-3-Carboxylic Acid Methyl Ester
CAS No.	959958-24-8
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	Methyl 4-hydroxypiperidine-3-carboxylate; 3-Piperidinecarboxylic acid, 4-hydroxy-, methyl ester; Methyl 4-hydroxy-3-piperidinecarboxylate; 4-Hydroxy-3-piperidinecarboxylic acid methyl ester; 959958-24-8; 4-Hydroxypiperidine-3-carboxylic acid methyl ester; Methyl 4-hydroxynipecotate
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-Piperidine-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.