Description

2-Ethynylpiperidine is a specialized piperidine derivative featuring a reactive terminal alkyne group, making it a valuable building block in advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the piperidine scaffold and alkyne functionality impart specific biological activity.
• Ligand Synthesis for Catalysis: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysis, enhancing reaction selectivity and efficiency.
• Material Science Building Block: Acts as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Click Chemistry Reagent: The terminal alkyne group enables its use in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer modification.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying biological pathways and protein function.

Basic Information

Item	Details
Product Name	2-Ethynylpiperidine
CAS No.	959918-17-3
Molecular Formula	C7H11N
Molecular Weight	109.17 g/mol
Synonyms	2-Ethynylpiperidine; 2-Ethynyl-piperidine; Piperidine, 2-ethynyl-; 2-Piperidinylacetylene; 2-(Ethynyl)piperidine; 2-Piperidylethyne; 2-Ethynylazacyclohexane
EINECS	Contact for details

Quality Control

Our 2-Ethynylpiperidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We adhere to cGMP principles for pharmaceutical intermediates, and our quality systems are designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.