Description

(2S,4S)-1-(tert-Butoxycarbonyl)-4-(Furan-2-Ylmethyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a stereochemically defined pyrrolidine core protected by a Boc group. This compound is a critical chiral building block for the synthesis of complex molecules, offering precise control over stereochemistry and molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeting specific enzymes.
• Peptidomimetics Synthesis: Used to construct constrained peptide analogs where the pyrrolidine ring introduces conformational rigidity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in lead optimization.
• Chemical Biology Probes: Incorporated into molecules designed to study biological pathways and protein function.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to generate enantiomerically pure products.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	(2S,4S)-1-(tert-Butoxycarbonyl)-4-(Furan-2-Ylmethyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959583-73-4
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	Boc-4-(2-Furylmethyl)-L-proline; (2S,4S)-1-Boc-4-(2-Furanylmethyl)-2-pyrrolidinecarboxylic Acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(2-furanyl)methyl]-2-pyrrolidinecarboxylic Acid, (2S,4S)-; (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2-Furylmethyl)pyrrolidine-2-carboxylic Acid; (2S,4S)-1-Boc-4-(furan-2-ylmethyl)pyrrolidine-2-carboxylic Acid; (2S,4S)-4-(Furan-2-ylmethyl)-1-((tert-butoxy)carbonyl)pyrrolidine-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for chiral purity (enantiomeric excess), chemical purity (HPLC), and other critical parameters are available upon request. We adhere to a cGMP-compliant quality management system for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.